Synthesis and Antibacterial Activity Screening of Some Novel Pyrazole Derivatives

Objective: To synthesise a series of quinazolinone clubbed pyrazole derivatives and evaluate for their antibacterial activity. Method: Various Quinazolinone clubbed Pyrazole derivative compounds were synthesized as per standard chemical procedure and characterized by physical and spectral analysis. The antimicrobial activities of all the synthesized compounds were evaluated separately for their possible antimicrobial activity against common pathogenic bacteria. Bacteria used in the present study were Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), as gram positive and Escherichia coli (E. Coli), Pseudomonas aeruginosa (P. aeruginosa) as gram negative bacteria. The study was conducted by cup-plate method. Result: The antibacterial data’s of the newly synthesized compounds indicate that some of them show better antibacterial activity than compared to their reference drug Ampicilin. Conclusion: Four (7a1, 7a2, 7b1, 7b2) new biologically active pyrazole were synthesized for the first time. Synthesized compounds exhibited good antibacterial activity against the tested microorganism.